Calcium ion import across plasma membrane

Across TCGA patient cohorts, RNA activity of the Calcium ion import across plasma membrane pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SNTB2_S208, TGFB1I1_S194, and CD99L2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Calcium ion import across plasma membrane activity versus SNTB2_S208 in UCEC (Pearson r = 0.05).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SNTB2_S208 →	+0.650	+0.057	<.001	<.001	3	5
UCEC	TGFB1I1_S194 →	+0.728	+0.038	<.001	.001	3	5
GBM	CD99L2 →	+0.314	+0.054	<.001	<.001	3	5
UCEC	HMGN4 →	+0.510	+0.043	.001	.006	3	5
LSCC	BRIX1 →	-0.373	-0.048	<.001	<.001	3	5
LUAD	MTMR6 →	+0.119	+0.038	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098703 vs SNTB2_S208 — UCEC

Explore this scatter interactively →