Calcium ion import across plasma membrane

Across TCGA patient cohorts, RNA activity of the Calcium ion import across plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC8A1, PPP1R16B, and ITM2A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Calcium ion import across plasma membrane activity versus SLC8A1 in HNSC (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SLC8A1 →	+0.550	+0.595	<.001	<.001	3	6
HNSC	PPP1R16B →	+1.224	+0.818	<.001	<.001	3	5
HNSC	ITM2A →	+1.041	+0.589	<.001	<.001	3	5
HNSC	MS4A6A →	+0.692	+0.542	<.001	<.001	3	5
HNSC	IL10RA →	+1.075	+0.717	<.001	<.001	3	5
HNSC	FAM124B →	+0.539	+0.641	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098703 vs SLC8A1 — HNSC

Explore this scatter interactively →