Calcium ion import across plasma membrane

Across TCGA cell cohorts, RNA activity of the Calcium ion import across plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PEX16, ADAT3, and NKX2-5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PEX16 grouped by Calcium ion import across plasma membrane-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	PEX16 →	-0.900	-1.431	.003	.001	3	4
BLOOD_Myeloma	ADAT3 →	-1.174	-1.330	.003	.001	3	4
URINARY_TRACT	NKX2-5 →	+2.899	+0.282	<.001	<.001	2	4
CNS	BFAR →	+0.340	+0.766	.002	<.001	3	3
CNS	PURB →	+0.671	+0.758	<.001	.004	3	3
CNS	BTN3A1 →	+0.784	+0.700	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PEX16 by Calcium ion import across plasma membrane activity — BLOOD_Myeloma

Explore this box plot interactively →