Regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

Across TCGA patient cohorts, RNA activity of the Regulation of neurotransmitter receptor localization to postsynaptic specialization membrane pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NCAPH, NEK2, and CENPF, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of neurotransmitter receptor localization to postsynaptic specialization membrane activity versus NCAPH in UCEC (Pearson r = -0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NCAPH →	-0.616	-0.197	<.001	.004	3	4
LUAD	NEK2 →	-1.212	-0.275	<.001	.007	3	4
PDAC	CENPF →	-0.529	-0.112	.002	.002	3	4
PDAC	TOP2A →	-0.526	-0.138	.008	<.001	3	4
UCEC	BUB1 →	-0.817	-0.212	<.001	.002	3	4
UCEC	DIAPH3 →	-0.689	-0.194	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098696 vs NCAPH — UCEC

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