Regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of neurotransmitter receptor localization to postsynaptic specialization membrane pathway is associated with patient survival in 25 of 34 cancer lineages. Pathway activity is summarized from the expression of its 11 member genes.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher Regulation of neurotransmitter receptor localization to postsynaptic specialization membrane pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as ESCA and LUAD, show the opposite pattern, with higher activity associated with better survival.

UCEC, ESCA, and ACC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	All	0.836	0.906	.009	44	view →
ESCA	OS	Quartile	III,IV	0.715	0.279	<.001	42	view →
ACC	DFS	Tertile	All	0.322	0.770	<.001	39	view →
UVM	DFS	Quartile	III,IV	0.314	0.874	<.001	33	view →
PCPG	DFS	Median	All	0.487	0.935	<.001	30	view →
LUSC	OS	Median	IV	0.057	0.786	.008	27	view →
SARC	DFS	Tertile	All	0.203	0.439	.001	26	view →
COAD	DFS	Median	IV	0.322	0.574	.002	26	view →
THCA	OS	Median	All	0.776	1.000	.002	24	view →
LUAD	OS	Quartile	II,III,IV	0.663	0.392	.015	15	view →
MESO	OS	Tertile	All	0.612	0.235	.019	15	view →
KIRP	DFS	Quartile	IV	0.083	0.794	.010	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

GO:0098696–UCEC (OS)

Open the UCEC breakdown →