Detection of external biotic stimulus

Across TCGA patient cohorts, RNA activity of the Detection of external biotic stimulus pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LCP2, C5orf58, and MEFV, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Detection of external biotic stimulus activity versus LCP2 in LSCC (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	LCP2 →	+0.817	+0.405	<.001	<.001	3	7
HNSC	C5orf58 →	+0.630	+0.181	<.001	<.001	3	6
LSCC	MEFV →	+0.638	+0.311	<.001	<.001	3	6
GBM	ITGAX →	+0.780	+0.303	.005	<.001	3	6
PDAC	FCAR →	+0.624	+0.203	.001	.001	3	6
BRCA	RIN3 →	+0.579	+0.202	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098581 vs LCP2 — LSCC

Explore this scatter interactively →