De novo centriole assembly involved in multi-ciliated epithelial cell differentiation

Across TCGA patient cohorts, RNA activity of the De novo centriole assembly involved in multi-ciliated epithelial cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC78, CEP152, and CENPJ, each associated with the pathway in up to 31 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, De novo centriole assembly involved in multi-ciliated epithelial cell differentiation activity versus CCDC78 in GBM (Pearson r = 0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CCDC78 →	+1.323	+0.077	<.001	<.001	3	31
UVM	CEP152 →	+0.969	+0.076	<.001	<.001	3	30
UVM	CENPJ →	+1.385	+0.072	<.001	<.001	3	29
THYM	BUB1B →	+1.520	+0.092	<.001	<.001	3	29
ACC	CCNB2 →	+1.718	+0.047	<.001	<.001	3	29
ACC	FANCA →	+0.970	+0.058	<.001	<.001	3	29

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098535 vs CCDC78 — GBM

Explore this scatter interactively →