De novo centriole assembly involved in multi-ciliated epithelial cell differentiation

Across TCGA patient cohorts, RNA activity of the De novo centriole assembly involved in multi-ciliated epithelial cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LFNG, ESCO2, and ARHGAP11B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, De novo centriole assembly involved in multi-ciliated epithelial cell differentiation activity versus LFNG in BRCA (Pearson r = -0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LFNG →	-1.363	-0.145	<.001	.002	3	4
BRCA	ESCO2 →	+0.877	+0.119	<.001	.003	3	4
LUAD	ARHGAP11B →	+0.440	+0.236	<.001	.001	3	4
BRCA	THSD4 →	-2.155	-0.174	<.001	<.001	3	4
BRCA	MIR924HG →	+0.337	+0.096	<.001	<.001	3	4
LUAD	SLC26A5 →	-0.708	-0.121	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098535 vs LFNG — BRCA

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