Centriole assembly

Across TCGA patient cohorts, RNA activity of the Centriole assembly pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MCM6, VRK1, and RRM2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Centriole assembly activity versus MCM6 in LUAD (Pearson r = 0.55).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MCM6 →	+0.726	+0.055	<.001	<.001	3	10
GBM	VRK1 →	+0.552	+0.067	<.001	<.001	3	10
GBM	RRM2 →	+0.903	+0.066	<.001	<.001	3	9
GBM	SMC2 →	+0.660	+0.064	<.001	<.001	3	9
BRCA	SMC4 →	+0.612	+0.037	<.001	<.001	3	9
GBM	THOC1 →	+0.288	+0.041	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098534 vs MCM6 — LUAD

Explore this scatter interactively →