Centriole assembly

Across TCGA pan-cancer cohorts, RNA activity of the Centriole assembly pathway is associated with patient survival in 27 of 34 cancer lineages. Pathway activity is summarized from the expression of its 49 member genes.

The strongest signal is observed in mesothelioma (MESO), where higher Centriole assembly pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and UCS, show the opposite pattern, with higher activity associated with better survival.

MESO, ACC, and KIRC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	III,IV	0.408	0.668	<.001	126	view →
ACC	DFS	Median	All	0.276	0.769	<.001	115	view →
KIRC	DFS	Tertile	All	0.459	0.714	<.001	89	view →
LIHC	DFS	Median	All	0.449	0.627	<.001	79	view →
HNSC	OS	Tertile	All	0.802	0.634	<.001	71	view →
KICH	DFS	Median	All	0.667	0.951	.001	61	view →
LGG	DFS	Median	All	0.629	0.836	<.001	54	view →
KIRP	DFS	Tertile	All	0.639	0.803	<.001	34	view →
PAAD	OS	Quartile	All	0.456	0.693	.004	31	view →
UCS	OS	Median	II,III,IV	0.602	0.266	.018	30	view →
UVM	DFS	Tertile	III,IV	0.242	0.780	.006	27	view →
GBM	DFS	Quartile	All	0.558	0.242	.003	21	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

GO:0098534–MESO (OS)

Open the MESO breakdown →