Calcium ion transmembrane import into cytosol

Across TCGA cell cohorts, RNA activity of the Calcium ion transmembrane import into cytosol pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GIT1, BRD4, and TULP3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Calcium ion transmembrane import into cytosol activity versus GIT1 in PANCREAS (Pearson r = -0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	GIT1 →	-0.797	-0.257	.005	.002	3	5
BONE	BRD4 →	-0.817	-0.295	.002	.004	3	4
BONE	TULP3 →	-1.360	-0.423	.002	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	WIZ →	-0.727	-0.328	.002	.003	3	4
SKIN	DCUN1D2 →	-0.811	-0.279	.002	.004	3	4
OESOPHAGUS	IFIT2 →	+1.827	+0.224	.004	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097553 vs GIT1 — PANCREAS

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