Calcium ion transmembrane import into cytosol

Across TCGA pan-cancer cohorts, RNA activity of the Calcium ion transmembrane import into cytosol pathway differs between tumor and matched normal tissue in 11 of the 18 cancer types tested.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where pathway activity is lower in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as BLCA and LUSC, show the opposite pattern, with lower activity in tumor tissue.

BLCA, KIRC, and LUSC show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
BLCA	Male	All	−0.039	<.001	11	view →
KIRC	Female	All	+0.027	<.001	11	view →
LUSC	Male	III,IV	−0.060	<.001	8	view →
LUAD	All	III,IV	−0.029	<.001	7	view →
BRCA	All	All	−0.013	<.001	6	view →
THCA	All	All	−0.013	<.001	4	view →
COAD	All	All	−0.010	.009	4	view →
LIHC	Male	All	−0.010	.011	3	view →
UCEC	All	All	−0.037	<.001	2	view →
KIRP	Female	II,III,IV	−0.018	.003	2	view →
HNSC	All	II,III,IV	+0.010	.039	1	view →

Pink = more active in tumor, green = less active in tumor. Showing the 11 strongest of 11 lineages.

GO:0097553–BLCA

Open the BLCA breakdown →