Protein localization to non-motile cilium

Across TCGA patient cohorts, RNA activity of the Protein localization to non-motile cilium pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC157, LRRTM2, and GLB1L, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to non-motile cilium activity versus CCDC157 in LSCC (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CCDC157 →	+0.184	+0.445	.003	.007	3	4
HNSC	LRRTM2 →	-0.591	-0.229	.008	.009	3	3
GBM	GLB1L →	+0.412	+0.480	.001	.003	3	3
COAD	CSF2RA →	-1.308	-0.126	.007	.004	3	3
BRCA	PEX16 →	+0.500	+0.653	.003	.001	3	3
BRCA	RNF25 →	+0.401	+0.543	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097499 vs CCDC157 — LSCC

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