Protein localization to non-motile cilium

Across TCGA cell cohorts, RNA activity of the Protein localization to non-motile cilium pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KAT2A, DHX58, and FAM243B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KAT2A grouped by Protein localization to non-motile cilium-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	KAT2A →	-0.558	-1.456	<.001	<.001	3	5
CNS	DHX58 →	+1.104	+0.749	.001	<.001	3	4
SOFT_TISSUE	FAM243B →	-0.390	-1.342	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	ARHGAP44 →	-0.471	-1.093	.002	.007	3	4
SOFT_TISSUE	BBS5 →	-1.176	-1.393	.006	.008	3	4
SOFT_TISSUE	GALNT11 →	-1.378	-1.474	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KAT2A by Protein localization to non-motile cilium activity — SOFT_TISSUE

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