Protein localization to non-motile cilium

Across TCGA cell cohorts, RNA activity of the Protein localization to non-motile cilium pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AMIGO2, QPRT, and MBNL3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to non-motile cilium activity versus AMIGO2 in BREAST (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	AMIGO2 →	+2.640	+1.081	.007	.002	3	4
BONE	QPRT →	-3.782	-1.555	.001	.001	3	4
OVARY	MBNL3 →	-1.454	-1.488	.001	<.001	2	5
BREAST	ZNF419 →	+0.973	+0.799	.002	.001	3	3
BREAST	FRAT2 →	-1.494	-0.775	.002	.009	2	4
LUNG_NSCLC_LUAD	SLC7A11 →	+2.038	+0.935	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097499 vs AMIGO2 — BREAST

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