Plasma membrane tubulation

Across TCGA patient cohorts, RNA activity of the Plasma membrane tubulation pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGA9, TAL1, and PLAC9, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Plasma membrane tubulation activity versus ITGA9 in CCRCC (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ITGA9 →	+0.582	+0.323	<.001	<.001	3	7
CCRCC	TAL1 →	+0.849	+0.351	<.001	<.001	3	7
CCRCC	PLAC9 →	+1.010	+0.485	<.001	.001	3	6
GBM	OSR1 →	+0.951	+0.340	.006	.001	3	6
LUAD	VSIR →	+0.713	+0.178	<.001	<.001	3	6
CCRCC	SCARF1 →	+0.473	+0.285	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097320 vs ITGA9 — CCRCC

Explore this scatter interactively →