Plasma membrane tubulation

Across TCGA pan-cancer cohorts, RNA activity of the Plasma membrane tubulation pathway is associated with patient survival in 19 of 34 cancer lineages. Pathway activity is summarized from the expression of its 19 member genes.

The strongest signal is observed in mesothelioma (MESO), where higher Plasma membrane tubulation pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as BRCA and ESCA, show the opposite pattern, with higher activity associated with better survival.

MESO, KIRC, and BRCA are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	DFS	Median	III,IV	0.266	0.447	.001	84	view →
KIRC	DFS	Median	III,IV	0.369	0.549	.002	80	view →
BRCA	DFS	Tertile	III,IV	0.683	0.367	.002	36	view →
ESCA	OS	Tertile	III,IV	0.682	0.287	.006	24	view →
LGG	DFS	Tertile	All	0.724	0.863	.002	15	view →
ACC	DFS	Tertile	II,III,IV	0.326	0.626	.011	12	view →
HNSC	DFS	Quartile	IV	0.598	0.349	.027	12	view →
PAAD	OS	Median	II,III,IV	0.455	0.324	.006	10	view →
LUSC	OS	Quartile	III,IV	0.195	0.885	.002	10	view →
THCA	OS	Quartile	All	0.947	1.000	.023	7	view →
UCS	OS	Tertile	All	0.152	0.481	.011	6	view →
SARC	OS	Quartile	All	0.901	0.750	.010	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

GO:0097320–MESO (DFS)

Open the MESO breakdown →