XMP metabolic process

Across TCGA patient cohorts, RNA activity of the XMP metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WDR36, MYBBP1A, and RFC4, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, XMP metabolic process activity versus WDR36 in LSCC (Pearson r = 0.55).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	WDR36 →	+0.314	+0.078	<.001	<.001	3	9
LUAD	MYBBP1A →	+0.446	+0.077	<.001	<.001	3	9
LSCC	RFC4 →	+0.412	+0.057	<.001	<.001	3	9
LUAD	SMC4 →	+0.607	+0.087	<.001	<.001	3	9
LUAD	TRIP13 →	+0.825	+0.089	<.001	<.001	3	9
LSCC	PPAT →	+0.433	+0.084	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097292 vs WDR36 — LSCC

Explore this scatter interactively →