Cellular response to toxic substance

Across TCGA patient cohorts, RNA activity of the Cellular response to toxic substance pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SNRPA1, CD36, and MAN1A1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to toxic substance activity versus SNRPA1 in GBM (Pearson r = -0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SNRPA1 →	-0.299	-0.139	<.001	.001	2	7
OV	CD36 →	+1.464	+0.213	<.001	<.001	3	6
OV	MAN1A1 →	+0.462	+0.158	.002	<.001	3	6
GBM	ACIN1 →	-0.265	-0.181	<.001	<.001	2	7
GBM	SERPINA5 →	+0.641	+0.192	<.001	<.001	3	6
UCEC	SOD3 →	+0.645	+0.164	.003	.001	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097237 vs SNRPA1 — GBM

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