Neuronal stem cell population maintenance

Across TCGA patient cohorts, RNA activity of the Neuronal stem cell population maintenance pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GATAD2B, POGZ, and ATAD2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuronal stem cell population maintenance activity versus GATAD2B in GBM (Pearson r = 0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	GATAD2B →	+0.426	+0.098	<.001	<.001	3	8
HNSC	POGZ →	+0.286	+0.098	<.001	<.001	3	8
GBM	ATAD2 →	+0.457	+0.092	.002	<.001	3	7
GBM	SMC2 →	+0.610	+0.088	.004	<.001	3	7
BRCA	MTA1_S576 →	+0.510	+0.029	.001	<.001	3	7
LSCC	ANP32E →	+0.499	+0.067	.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097150 vs GATAD2B — GBM

Explore this scatter interactively →