Neuronal stem cell population maintenance

Across TCGA pan-cancer cohorts, RNA activity of the Neuronal stem cell population maintenance pathway is associated with patient survival in 27 of 34 cancer lineages. Pathway activity is summarized from the expression of its 23 member genes.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher Neuronal stem cell population maintenance pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UCS and HNSC, show the opposite pattern, with higher activity associated with better survival.

ACC, MESO, and KIRP are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	All	0.266	0.859	<.001	142	view →
MESO	OS	Tertile	All	0.398	0.684	<.001	130	view →
KIRP	OS	Tertile	All	0.880	0.978	<.001	90	view →
UVM	DFS	Tertile	II,III,IV	0.377	0.750	<.001	90	view →
LIHC	OS	Quartile	All	0.619	0.849	<.001	70	view →
UCS	DFS	Median	All	0.695	0.396	.003	66	view →
HNSC	DFS	Tertile	IV	0.777	0.577	.004	45	view →
BLCA	DFS	Quartile	II,III,IV	0.495	0.642	.005	29	view →
THCA	OS	Median	II,III,IV	0.508	1.000	<.001	29	view →
KICH	OS	Median	All	0.755	0.970	.008	27	view →
LGG	OS	Tertile	All	0.710	0.851	<.001	27	view →
LUAD	OS	Quartile	All	0.582	0.775	<.001	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

GO:0097150–ACC (OS)

Open the ACC breakdown →