Neuronal stem cell population maintenance

Across TCGA patient cohorts, RNA activity of the Neuronal stem cell population maintenance pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AGPAT5, XPO7, and CCAR2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuronal stem cell population maintenance activity versus AGPAT5 in LUAD (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	AGPAT5 →	+0.506	+1.001	<.001	<.001	3	6
HNSC	XPO7 →	+0.604	+0.575	.005	.004	2	6
LSCC	CCAR2 →	+0.341	+0.772	.002	.001	3	5
LUAD	PBK →	+1.029	+0.909	<.001	<.001	3	5
GBM	ESCO2 →	+0.673	+0.636	.001	.001	3	5
GBM	CDCA2 →	+0.891	+0.713	.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097150 vs AGPAT5 — LUAD

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