Neuronal stem cell population maintenance

Across TCGA cell cohorts, RNA activity of the Neuronal stem cell population maintenance pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARMC4, CAPN5, and TLCD1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuronal stem cell population maintenance activity versus ARMC4 in URINARY_TRACT (Pearson r = 0.76).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	ARMC4 →	+2.876	+0.546	<.001	<.001	3	4
STOMACH	CAPN5 →	-1.932	-0.189	.003	.008	3	4
STOMACH	TLCD1 →	-1.179	-0.253	.002	.002	3	4
BLOOD_Lymphoma	SAMD10 →	-2.438	-0.189	.001	.001	3	4
URINARY_TRACT	DUSP11 →	-0.894	-0.473	<.001	<.001	3	4
LUNG_NSCLC_LUAD	PICALM →	+0.828	+0.186	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097150 vs ARMC4 — URINARY_TRACT

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