Synaptic vesicle clustering

Across TCGA patient cohorts, RNA activity of the Synaptic vesicle clustering pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are C1QTNF5, HCLS1, and GALM, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Synaptic vesicle clustering activity versus C1QTNF5 in HNSC (Pearson r = 0.13).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	C1QTNF5 →	+0.435	+0.065	.001	<.001	3	6
GBM	HCLS1 →	-0.642	-0.092	<.001	.001	3	6
GBM	GALM →	-0.453	-0.103	<.001	<.001	3	6
GBM	SIPA1_S839 →	-0.432	-0.074	.001	.007	3	6
LSCC	WDFY4 →	-0.369	-0.047	<.001	<.001	3	6
LSCC	EVI2B_S268 →	-0.682	-0.049	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097091 vs C1QTNF5 — HNSC

Explore this scatter interactively →