Synaptic vesicle clustering

Across TCGA pan-cancer cohorts, RNA activity of the Synaptic vesicle clustering pathway is associated with patient survival in 20 of 34 cancer lineages. Pathway activity is summarized from the expression of its 16 member genes.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher Synaptic vesicle clustering pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as KIRP and LGG, show the opposite pattern, with higher activity associated with better survival.

KIRP, ACC, and LGG are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Quartile	II,III,IV	0.895	0.529	.003	39	view →
ACC	OS	Tertile	II,III,IV	0.336	0.817	<.001	36	view →
LGG	OS	Median	All	0.937	0.857	<.001	36	view →
SKCM	DFS	Tertile	All	0.156	0.462	<.001	31	view →
KICH	OS	Tertile	III,IV	0.262	0.885	.003	24	view →
UVM	DFS	Median	III,IV	0.887	0.531	.015	18	view →
LAML	DFS	Tertile	All	0.590	0.322	.030	10	view →
LUAD	DFS	Quartile	III,IV	0.455	0.198	.021	9	view →
KIRC	DFS	Median	II,III,IV	0.679	0.805	.030	6	view →
CHOL	DFS	Tertile	III,IV	0.255	0.791	.047	6	view →
LIHC	OS	Median	All	0.827	0.735	.011	6	view →
ESCA	DFS	Tertile	All	1.000	0.496	.031	5	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

GO:0097091–KIRP (OS)

Open the KIRP breakdown →