Response to thyroxine

Across TCGA patient cohorts, RNA activity of the Response to thyroxine pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AGAP5, G6PD, and CDK12, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to thyroxine activity versus AGAP5 in HNSC (Pearson r = -0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	AGAP5 →	-0.193	-0.165	.003	<.001	3	3
LSCC	G6PD →	+1.141	+0.194	<.001	<.001	3	3
CCRCC	CDK12 →	+0.204	+0.139	.006	.004	3	3
CCRCC	HCFC1 →	+0.503	+0.148	.001	.002	3	3
CCRCC	RPS12P20 →	+0.596	+0.165	.001	<.001	3	3
CCRCC	ATXN7L3 →	+0.169	+0.088	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097068 vs AGAP5 — HNSC

Explore this scatter interactively →