Regulation of plasma lipoprotein particle levels

Across TCGA cell cohorts, RNA activity of the Regulation of plasma lipoprotein particle levels pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SGK1, ACVR2B, and WDR12, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SGK1 grouped by Regulation of plasma lipoprotein particle levels-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SGK1 →	-1.521	-1.014	.004	.007	3	4
OVARY	ACVR2B →	+0.653	+1.044	.002	.001	3	4
PANCREAS	WDR12 →	+0.554	+0.906	<.001	.004	3	4
CNS	PRKAG2 →	-1.434	-1.080	<.001	<.001	3	4
CNS	TMEM9B →	-0.494	-0.956	.003	<.001	3	4
CNS	OPA1 →	-0.510	-1.051	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SGK1 by Regulation of plasma lipoprotein particle levels activity — OESOPHAGUS

Explore this box plot interactively →