Immunological memory process

Across TCGA cell cohorts, RNA activity of the Immunological memory process pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPS6KA3, SOAT2, and RBP4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RPS6KA3 grouped by Immunological memory process-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	RPS6KA3 →	+0.141	+0.621	.001	.006	3	4
LUNG_SCLC	SOAT2 →	-0.336	-0.965	.002	.002	3	4
OVARY	RBP4 →	+0.215	+1.008	.005	.003	3	4
LUNG_NSCLC_LUAD	SRSF2 →	+0.245	+0.710	.001	<.001	3	4
OVARY	PPP4C →	-0.432	-1.292	.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	C2orf49 →	+0.315	+1.778	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RPS6KA3 by Immunological memory process activity — CNS

Explore this box plot interactively →