Mitochondrial tRNA processing

Across TCGA patient cohorts, RNA activity of the Mitochondrial tRNA processing pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GATB, CPSF3, and REPS1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial tRNA processing activity versus GATB in PDAC (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	GATB →	+0.271	+0.023	.006	.003	3	8
LSCC	CPSF3 →	+0.265	+0.055	<.001	<.001	3	6
LSCC	REPS1 →	+0.256	+0.050	<.001	<.001	3	6
BRCA	ZC3H8 →	+0.580	+0.023	<.001	.006	3	6
LSCC	RRP15 →	+0.359	+0.043	<.001	<.001	3	6
LSCC	SUPT16H →	+0.280	+0.036	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090646 vs GATB — PDAC

Explore this scatter interactively →