Podocyte cell migration

Across TCGA patient cohorts, RNA activity of the Podocyte cell migration pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MLLT11, TTC23L, and REM1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Podocyte cell migration activity versus MLLT11 in OV (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	MLLT11 →	+0.574	+0.453	.002	.001	3	3
COAD	TTC23L →	-0.060	-0.267	.003	.002	3	3
GBM	REM1 →	+0.444	+0.541	.007	<.001	3	3
LUAD	HOMER1 →	+0.433	+0.477	.003	.009	3	3
CCRCC	ABCC4 →	+0.346	+0.586	.003	.002	3	3
BRCA	KNSTRN →	+0.515	+0.538	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090521 vs MLLT11 — OV

Explore this scatter interactively →