Protein localization to nuclear envelope

Across TCGA patient cohorts, RNA activity of the Protein localization to nuclear envelope pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LMNA, ASPN, and MXRA8, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to nuclear envelope activity versus LMNA in BRCA (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LMNA →	+0.993	+0.213	<.001	<.001	3	6
LSCC	ASPN →	+0.877	+0.220	.002	.007	3	4
LSCC	MXRA8 →	+0.635	+0.226	.005	<.001	2	5
LSCC	COL15A1 →	+0.801	+0.247	.007	.002	3	4
UCEC	COL6A2 →	+0.985	+0.170	.001	<.001	3	4
BRCA	PRR5 →	+0.492	+0.179	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090435 vs LMNA — BRCA

Explore this scatter interactively →