Protein localization to nuclear envelope

Across TCGA cell cohorts, RNA activity of the Protein localization to nuclear envelope pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LGALS9, AGAP3, and PHF20L1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LGALS9 grouped by Protein localization to nuclear envelope-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	LGALS9 →	+2.540	+0.319	.002	.003	3	5
CNS	AGAP3 →	+0.803	+0.232	.001	.001	3	5
BLOOD_Myeloma	PHF20L1 →	+1.131	+0.262	<.001	.003	3	5
CNS	SLC9A3R2 →	+1.662	+0.166	.003	.006	3	5
PANCREAS	MX2 →	+2.477	+0.254	.007	.002	3	4
LIVER	TTC39C →	+1.510	+0.241	.007	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LGALS9 by Protein localization to nuclear envelope activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →