Cellular senescence

Across TCGA patient cohorts, RNA activity of the Cellular senescence pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TGFB3, TIMP2, and PPFIBP1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular senescence activity versus TGFB3 in OV (Pearson r = 0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TGFB3 →	+0.840	+0.056	<.001	<.001	3	7
BRCA	TIMP2 →	+0.844	+0.036	<.001	<.001	3	7
OV	PPFIBP1 →	+0.358	+0.043	.003	.004	3	7
OV	SULF1 →	+0.677	+0.049	<.001	<.001	3	6
BRCA	ANGPTL2 →	+0.712	+0.032	<.001	<.001	3	6
HNSC	IGFBP7 →	+0.502	+0.045	<.001	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090398 vs TGFB3 — OV

Explore this scatter interactively →