Cellular senescence

Across TCGA cell cohorts, RNA activity of the Cellular senescence pathway is significantly associated with the shRNA dependency of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRPF8, CYP2A7, and PCDHA11, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PRPF8 grouped by Cellular senescence-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	PRPF8 →	+0.548	+0.193	<.001	.006	3	5
SOFT_TISSUE	CYP2A7 →	-0.343	-0.242	<.001	<.001	3	4
SOFT_TISSUE	PCDHA11 →	-0.366	-0.356	.003	<.001	3	4
OVARY	LRP3 →	-0.220	-0.179	.006	.001	3	4
BLOOD_Leukemia	G6PD →	-0.162	-0.272	<.001	.001	3	4
LUNG_NSCLC_LUSC	FRMD6 →	-0.231	-0.173	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PRPF8 by Cellular senescence activity — LIVER

Explore this box plot interactively →