Positive regulation of brown fat cell differentiation

Across TCGA patient cohorts, RNA activity of the Positive regulation of brown fat cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are H4C1, HEXD-IT1, and ANAPC7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of brown fat cell differentiation activity versus H4C1 in HNSC (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	H4C1 →	+1.245	+0.614	.002	<.001	3	4
UCEC	HEXD-IT1 →	-0.578	-0.539	.001	.003	3	4
CCRCC	ANAPC7 →	+0.198	+0.559	.002	<.001	3	4
CCRCC	GCN1 →	+0.328	+0.404	<.001	<.001	3	4
HNSC	DDX55 →	+0.350	+0.610	.005	.002	2	4
HNSC	CDC20 →	+0.789	+0.608	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090336 vs H4C1 — HNSC

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