Positive regulation of brown fat cell differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of brown fat cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPM1M, MARVELD3, and GRHL1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of brown fat cell differentiation activity versus PPM1M in LIVER (Pearson r = 0.88).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	PPM1M →	+1.607	+0.446	.003	.001	3	6
LUNG_SCLC	MARVELD3 →	-2.244	-0.225	.005	.002	3	5
LUNG_NSCLC_LUAD	GRHL1 →	-1.977	-0.141	.001	.005	3	5
URINARY_TRACT	SLC9A8 →	+1.319	+0.294	.006	.005	3	5
SKIN	EXTL2 →	+0.714	+0.196	.001	.001	3	5
BREAST	DZIP1L →	+1.163	+0.162	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090336 vs PPM1M — LIVER

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