Negative regulation of platelet aggregation

Across TCGA patient cohorts, RNA activity of the Negative regulation of platelet aggregation pathway is significantly associated with the RNA expression of multiple genes, with the SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C1QTNF1, SH2B3, and SERPINE2, each associated with the pathway in up to 26 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of platelet aggregation activity versus C1QTNF1 in SCLC (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	C1QTNF1 →	+1.946	+0.181	<.001	<.001	3	26
SKCM	SH2B3 →	+0.714	+0.045	<.001	<.001	3	23
CHOL	SERPINE2 →	+2.974	+0.102	<.001	<.001	3	23
LIHC	AEBP1 →	+1.608	+0.056	<.001	<.001	3	22
CHOL	MMP19 →	+1.410	+0.075	.002	.005	1	24
CHOL	THBS1 →	+2.762	+0.101	<.001	.001	3	22

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090331 vs C1QTNF1 — SCLC

Explore this scatter interactively →