Regulation of DNA-templated DNA replication

Across TCGA patient cohorts, RNA activity of the Regulation of DNA-templated DNA replication pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMC2, SMC4, and BAZ1B_S349, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of DNA-templated DNA replication activity versus SMC2 in LUAD (Pearson r = 0.72).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SMC2 →	+0.765	+0.106	<.001	<.001	3	10
LUAD	SMC4 →	+0.749	+0.105	<.001	<.001	3	10
UCEC	BAZ1B_S349 →	+1.268	+0.131	<.001	<.001	3	10
LUAD	TOP2A_S1247 →	+1.524	+0.095	<.001	<.001	3	10
LSCC	UNG_T60 →	+1.063	+0.113	<.001	<.001	3	10
LUAD	FEN1 →	+0.507	+0.090	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090329 vs SMC2 — LUAD

Explore this scatter interactively →