Regulation of DNA-templated DNA replication

Across TCGA patient cohorts, RNA activity of the Regulation of DNA-templated DNA replication pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RFC1_S368, RFC4, and RFC5, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of DNA-templated DNA replication activity versus RFC1_S368 in OV (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RFC1_S368 →	+1.093	+0.849	<.001	<.001	3	8
LSCC	RFC4 →	+0.631	+0.742	<.001	<.001	3	8
BRCA	RFC5 →	+0.356	+1.049	<.001	<.001	3	8
GBM	RFC3 →	+0.395	+1.305	<.001	<.001	2	9
LSCC	NCBP2 →	+0.354	+0.754	<.001	<.001	3	8
BRCA	TOP2A_S1106 →	+0.957	+0.588	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090329 vs RFC1_S368 — OV

Explore this scatter interactively →