Negative regulation of protein targeting to membrane

Across TCGA patient cohorts, RNA activity of the Negative regulation of protein targeting to membrane pathway is significantly associated with the RNA expression of multiple genes, with the TGCT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DMTN, ITGB1BP1, and SEC24A, each associated with the pathway in up to 23 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of protein targeting to membrane activity versus DMTN in TGCT (Pearson r = 0.81).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
TGCT	DMTN →	+1.900	+0.150	<.001	<.001	3	23
CHOL	ITGB1BP1 →	+0.981	+0.075	.005	.009	1	22
DLBC	SEC24A →	-0.780	-0.058	.001	<.001	3	19
SARC	ROM1 →	+0.543	+0.041	<.001	<.001	3	19
THYM	PALM →	+1.216	+0.052	<.001	<.001	3	19
OV	INPP5K →	+0.548	+0.060	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090315 vs DMTN — TGCT

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