Negative regulation of protein targeting to membrane

Across TCGA pan-cancer cohorts, RNA activity of the Negative regulation of protein targeting to membrane pathway differs between tumor and matched normal tissue in 9 of the 18 cancer types tested.

The strongest signal is observed in kidney chromophobe (KICH), where pathway activity is lower in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as KICH and BRCA, show the opposite pattern, with lower activity in tumor tissue.

KICH, LIHC, and BRCA show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
KICH	Male	All	−0.110	<.001	8	view →
LIHC	Female	All	+0.070	<.001	7	view →
BRCA	All	II,III,IV	−0.126	<.001	6	view →
HNSC	Female	IV	−0.094	<.001	4	view →
THCA	All	All	+0.026	<.001	4	view →
CHOL	All	All	+0.169	<.001	3	view →
PRAD	All	All	−0.020	.019	2	view →
BLCA	Male	III,IV	−0.097	.034	1	view →
STAD	All	II,III,IV	−0.033	.042	1	view →

Pink = more active in tumor, green = less active in tumor. Showing the 9 strongest of 9 lineages.

GO:0090315–KICH

Open the KICH breakdown →