Mitotic spindle assembly

Across TCGA patient cohorts, RNA activity of the Mitotic spindle assembly pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CDK1, KIF2C, and TOP2A_S1106, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitotic spindle assembly activity versus CDK1 in UCEC (Pearson r = 0.17).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CDK1 →	+0.929	+0.240	<.001	.002	3	5
UCEC	KIF2C →	+1.030	+0.230	<.001	.006	3	5
UCEC	TOP2A_S1106 →	+1.366	+0.218	.003	.009	2	5
UCEC	TOPBP1 →	+0.454	+0.202	<.001	<.001	3	4
LUAD	UFD1_S247 →	+0.897	+0.204	<.001	<.001	3	4
UCEC	UHRF1 →	+0.776	+0.320	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090307 vs CDK1 — UCEC

Explore this scatter interactively →