Regulation of osteoclast proliferation

Across TCGA cell cohorts, RNA activity of the Regulation of osteoclast proliferation pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF875, USP25, and FAM118A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF875 grouped by Regulation of osteoclast proliferation-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ZNF875 →	+1.246	+1.402	<.001	<.001	3	4
BREAST	USP25 →	+0.634	+0.431	.001	.009	3	4
OVARY	FAM118A →	-0.946	-0.513	.004	.005	3	3
SKIN	PUS1 →	-0.445	-1.030	.004	<.001	3	3
KIDNEY	NAT14 →	+1.198	+1.304	.009	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	SLC27A5 →	-0.782	-0.740	.004	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF875 by Regulation of osteoclast proliferation activity — PANCREAS

Explore this box plot interactively →