Negative regulation of calcium ion import

Across TCGA patient cohorts, RNA activity of the Negative regulation of calcium ion import pathway is significantly associated with the RNA expression of multiple genes, with the ESCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACE, SLC30A1, and ADCY4, each associated with the pathway in up to 19 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of calcium ion import activity versus ACE in ESCA (Pearson r = -0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	ACE →	+1.440	+0.144	<.001	<.001	3	19
THYM	SLC30A1 →	+0.962	+0.067	<.001	<.001	3	19
KIRC	ADCY4 →	+0.874	+0.073	<.001	<.001	3	19
BLCA	MMRN2 →	+1.029	+0.062	<.001	<.001	3	19
ESCA	PTPRB →	+1.084	+0.119	<.001	<.001	3	18
KIRC	ARHGEF15 →	+0.906	+0.068	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090281 vs ACE — ESCA

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