Negative regulation of calcium ion import

Across TCGA pan-cancer cohorts, RNA activity of the Negative regulation of calcium ion import pathway is associated with patient survival in 20 of 34 cancer lineages. Pathway activity is summarized from the expression of its 9 member genes.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher Negative regulation of calcium ion import pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as KIRC and SARC, show the opposite pattern, with higher activity associated with better survival.

READ, LIHC, and KIRC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	DFS	Median	All	0.264	0.670	<.001	82	view →
LIHC	DFS	Tertile	All	0.415	0.627	<.001	76	view →
KIRC	DFS	Median	IV	0.502	0.218	.001	66	view →
LUSC	DFS	Tertile	II,III,IV	0.275	0.496	.002	43	view →
SARC	DFS	Tertile	All	0.506	0.245	.003	28	view →
UCS	OS	Tertile	IV	0.189	0.781	.038	24	view →
OV	DFS	Median	II,III,IV	0.589	0.494	.006	20	view →
SCLC	DFS	Median	II,III,IV	0.452	0.720	.005	20	view →
LAML	DFS	Tertile	All	0.316	0.577	.019	16	view →
STAD	DFS	Median	II,III,IV	0.381	0.599	.018	12	view →
TGCT	DFS	Quartile	All	0.479	0.754	.020	12	view →
GBM	OS	Quartile	All	0.530	0.332	.018	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

GO:0090281–READ (DFS)

Open the READ breakdown →