Negative regulation of calcium ion import

Across TCGA patient cohorts, RNA activity of the Negative regulation of calcium ion import pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNA5SP144, RPL29P19, and WASF3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of calcium ion import activity versus RNA5SP144 in LUAD (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNA5SP144 →	+0.634	+0.573	.001	.002	3	3
LUAD	RPL29P19 →	-0.399	-0.400	<.001	.004	3	3
OV	WASF3 →	-0.678	-0.389	<.001	.002	3	3
HNSC	RNU6-208P →	-0.663	-0.151	.001	<.001	3	2
HNSC	LINC01433 →	-0.330	-0.144	.007	.005	3	2
PDAC	TEX14 →	-0.229	-0.337	.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090281 vs RNA5SP144 — LUAD

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