Negative regulation of calcium ion import

Across TCGA cell cohorts, RNA activity of the Negative regulation of calcium ion import pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLCXD2, ARRDC4, and MICU2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PLCXD2 grouped by Negative regulation of calcium ion import-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PLCXD2 →	-2.118	-1.367	<.001	<.001	3	4
LARGE_INTESTINE	ARRDC4 →	-1.005	-1.018	.007	.001	3	4
KIDNEY	MICU2 →	-0.627	-1.267	.007	.003	2	5
OVARY	C11orf49 →	+0.802	+1.272	<.001	<.001	3	4
SOFT_TISSUE	CKAP5 →	+0.705	+1.235	.008	.004	3	4
LUNG_SCLC	EHD2 →	+3.522	+1.007	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PLCXD2 by Negative regulation of calcium ion import activity — LUNG_SCLC

Explore this box plot interactively →