Negative regulation of calcium ion import

Across TCGA cell cohorts, RNA activity of the Negative regulation of calcium ion import pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ROMO1, TTC8, and PPP3CA, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of calcium ion import activity versus ROMO1 in BREAST (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ROMO1 →	+0.832	+1.428	.005	.002	3	3
LARGE_INTESTINE	TTC8 →	+0.845	+1.473	.005	<.001	2	4
CNS	PPP3CA →	+1.299	+1.597	.003	<.001	3	3
CNS	BAIAP3 →	+1.492	+1.591	.005	<.001	3	3
BONE	KDM5A →	+1.140	+1.530	.005	<.001	3	3
LUNG_NSCLC_LUAD	SPON2 →	+3.122	+1.620	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090281 vs ROMO1 — BREAST

Explore this scatter interactively →