Positive regulation of calcium ion import

Across TCGA patient cohorts, RNA activity of the Positive regulation of calcium ion import pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TSPAN13, COG7, and FAM43B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of calcium ion import activity versus TSPAN13 in BRCA (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TSPAN13 →	+0.698	+0.163	.002	<.001	3	4
BRCA	COG7 →	+0.625	+0.189	<.001	.001	3	3
BRCA	FAM43B →	+0.329	+0.187	<.001	<.001	3	3
BRCA	MOSMO →	+0.515	+0.200	<.001	<.001	3	3
COAD	RN7SL589P →	+0.280	+0.128	<.001	<.001	3	3
BRCA	TGFB3 →	+1.094	+0.234	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090280 vs TSPAN13 — BRCA

Explore this scatter interactively →