Positive regulation of mitotic cell cycle spindle assembly checkpoint

Across TCGA cell cohorts, RNA activity of the Positive regulation of mitotic cell cycle spindle assembly checkpoint pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TTC9, MAPK13, and LSM10, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TTC9 grouped by Positive regulation of mitotic cell cycle spindle assembly checkpoint-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TTC9 →	+1.636	+0.197	<.001	.001	3	5
URINARY_TRACT	MAPK13 →	+3.957	+0.186	.002	.002	3	5
BLOOD_Myeloma	LSM10 →	-0.718	-0.145	.001	.006	3	5
URINARY_TRACT	ZC3H12A →	+1.451	+0.193	.001	<.001	3	5
STOMACH	SGTB →	-1.397	-0.197	.001	.004	3	5
OVARY	CNKSR1 →	+1.730	+0.161	.003	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TTC9 by Positive regulation of mitotic cell cycle spindle assembly checkpoint activity — LUNG_SCLC

Explore this box plot interactively →